Olga Tsoy
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I’m an assistant professor in bioinformatics at VU Amsterdam.
I graduated from Lomonosov Moscow State University (Moscow, Russia) and did a PhD in Kharkevich Institute in Moscow (Professor Mikhail Gelfand's lab). There, I studied the evolution of transcriptional regulatory networks in bacteria. During my PhD, I also worked at Stowers Institute for Medical Research (Kansas City, USA) and at Okinawa Institute of Science and Technology (Okinawa, Japan), where I continued working on the regulation of bacterial metabolic pathways. As a research scientist, I worked at the Skolkovo Institute of Science and Technology (Moscow, Russia) on 3D chromatin structure analysis. In 2019, I joined the group of Professor Jan Baumbach at the Technical University of Munich (Germany) and continued working with the group as a group leader at the University of Hamburg (Germany). In 2025, I joined VU Amsterdam as an assistant professor.
My main research interest is disease and side effects mechanism discovery using network biology approaches. The other focus is on the role of alternative splicing in pathological conditions, particularly driven by molecular interactions rewiring.
Albrecht E, Pelz K, Gress A, Nguyen H, Kalinina O, Kacprowski T, Baumbach J, List M, Tsoy O (2025) DIGGER 2.0: Digging Into the Functional Impact of Differential Splicing on Human and Mouse Disorders. Nucleic Acids Res. 2025 May 8:gkaf384. doi: 10.1093/nar/gkaf384.
Firoozbakht F, Elkjaer ML, Handy DE, Wang E, Chervontseva Z, Rarey M, Loscalzo J, Baumbach J*, Tsoy O* (2025) DREAMER: Exploring Common Mechanisms of Adverse Drug Reactions and Disease Phenotypes through Network-Based Analysis. Cell Rep. Methods 2025 Feb 24;5(2):100990. doi: 10.1016/j.crmeth.2025.100990. (download from ScienceDirect).
Hoffmann M, Poschenrieder J, Incudini M, Baier S, Fritz A, Maier A, Hartung M, Hoffmann C, Trummer N, Adamowicz K, Picciani M, Scheibling E, Harl M, Lesch I, Frey H, Kayser S, Wissenberg P, Schwartz L, Hafner L, Acharya A, Hackl L M, Grabert G, Lee S G, Cho G, Cloward M, Jankowski J, Lee H K, Tsoy O, Wenke N, Pedersen A, Bønnelykke K, Mandarino A, Melograna F, Schulz L, Climente-González H, Wilhelm M, Iapichino L, Wienbrandt L, Ellinghaus D, Van Steen K, Grossi M, Furth P, Hennighausen L, Di Pierro A, Baumbach J*, Kacprowski T*, List M*, Blumenthal D* (2024) Network medicine-based epistasis detection in complex diseases: ready for quantum computing. Nucleic Acids Res.